RefleXion featured by the Society for Radiation Oncology Administrators

Biology-Guided Radiotherapy: A New Modality in Cancer Care?

When Sam Mazin and Akshay Nanduri met in grade 9 science class at Thornlea Secondary School in Thornhill, Ontario, Canada, neither could have imagined they would one day create a bio-targeting oncology company that is poised to transform cancer care. They became fast friends, continually challenging each other to succeed. They studied computer engineering together at the University of Waterloo in Waterloo, Ontario. Graduate school and life took them down separate paths, but they remained in close contact.

Mazin pursued graduate studies at Stanford University where he studied electrical engineering with a focus on medical imaging. He developed expertise in CT and PET imaging systems. “I got interested in healthcare and the ability to apply engineering principles to see inside the body,” he said. While attending a lecture about radiation therapy in 2007, which Mazin admitted he didn’t know much about at the time, an idea came to him: “If in PET imaging a cancer cell emits a photon, why not just shoot one back with radiation?” He reached out to Nanduri to discuss his idea and about partnering in a business venture. They developed a plan and submitted it to the Massachusetts Institute of Technology’s business plan competition. They didn’t win, but they co-founded RefleXion Medical in 2009 and have never looked back. “He’s the guy I trust more than anyone,” Mazin said. “We’re both engineers by training, but with Akshay’s business background, he’s able to be the business guy to my technical counterpart.”

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